pmid: 31721533,   nlmid 101566618,  doi:10.22074/cellj.2020.6458

The Dilemma of TP53 Codon 72 Polymorphism (rs1042522) and Breast Cancer Risk: A Case-Control Study and Meta-Analysis in The Iranian Population.

Afzaljavan, Fahimeh Chaeichi Tehrani, Negin Rivandi, Mahdi Zarif Ghasemian, Saeed Vahednia, Elham Khayami, Reza Abavisani, Mohammad Pasdar, Alireza

Vol. 22, Issue 22, Jul.2020

Cell journal (Cell J),  ISSN 2228-5806


Mutations of TP53 as a tumor suppressor gene are frequently observed in different types of cancer. A codon 72 polymorphism located on exon 4 with two alleles encoding either Proline (CCC) or Arginine (CGC) has been indicated as a common variation in association with cancers. Controversial results have been reported regarding the association of allelic polymorphism of codon 72 of TP53 gene and breast cancer risk in Iranian patients. Therefore, a case-control study was designed. A meta-analysis was also carried out to provide evidence of association between this variation and breast cancer in Iran, based on all available published data. In this case-control study, blood sample of 622 participants, including 308 breast cancer cases and 314 controls were collected. Genotyping for rs1042522 was conducted by Allele Specific polymerase chain reaction (AS-PCR). In order to set a meta-analysis study, PubMed, Scopus and ISI Web of Knowledge and Persian databases were searched to explore relevant studies, published up to September 2018, containing information on TP53 polymorphism and the risk of breast cancer in Iran. Statistical analysis was performed using SPSS 16.0 and MetaGenyo. All retrieved available data as well as the results of our current study were consisted of 1965 breast cancer cases and 1999 healthy controls. No significant difference was observed in allele frequencies between groups (P=0.90) in our study. The cumulative results did not also show any association between rs1042522 and breast cancer risk on the dominant (P=0.61) and recessive (P=0.89) models. These findings cannot support contribution of rs1042522 polymorphism to breast cancer risk in an Iranian population. Future larger studies may help confirm this finding with a greater power.

MESH Headings

Article Keywords

Breast Cancer | Genetic Variation | Polymorphism | TP53 |


Similar Articles

Polymorphism of TP53 codon 72 showed no association with breast cancer in Iranian women.
Khadang, Baharak Fattahi, Mohammad Javad Talei, Abdolrasol Dehaghani, Alamtaj Samsami Ghaderi, Abbas
Cancer genetics and cytogenetics ,vol(173), issue(1),  Feb.2007

The TP53 Codon 72 Polymorphism and Risk of Sporadic Prostate Cancer among Iranian Patients.
Babaei, Farhad Ahmadi, Seyed Ali Abiri, Ramin Rezaei, Farhad Naseri, Maryam Mahmoudi, Mahmoud Nategh, Rakhshande Mokhtari Azad, Talat
Iranian journal of public health ,vol(43), issue(4),  Apr.2014

No significant association between the TP53 codon 72 polymorphism and breast cancer risk: a meta-analysis of 21 studies involving 24,063 subjects.
Ma, Yanlei Yang, Jianjun Liu, Zhihua Zhang, Peng Yang, Zhe Wang, Yu Qin, Huanlong
Breast cancer research and treatment ,vol(125), issue(1),  Jan.2011

Association between a single nucleotide polymorphism in the TP53 region and risk of ovarian cancer.
Xi, Yanni Liu, Congrong Xin, Xiaoyan
Cell biochemistry and biophysics ,vol(70), issue(3),  Dec.2014

No association of TP53 codon 72 SNP with male infertility: a study in a Chinese population and a meta-analysis.
Chan, Ying Jiang, Hongguo Ma, Lan Chen, Jinbao Li, Dongya Meng, Yushi Luo, Ying Tang, Wenru
Systems biology in reproductive medicine ,vol(61), issue(4),  

The TP53 codon 72 Pro/Pro genotype may be associated with an increased lung cancer risk in North China: an updated meta-analysis.
Wang, Xin Hao, Li-Ran Yue, Kai
International journal of clinical and experimental medicine ,vol(8), issue(3),  

Association between TP53 rs1042522 gene polymorphism and the risk of malignant bone tumors: a meta-analysis.
Huang, Xin Wu, Fashuai Zhang, Zhicai Shao, Zengwu
Bioscience reports ,vol(39), issue(3),  Mar.2019

Analysis of the R72P polymorphism of the TP53 gene in patients with invasive ductal breast carcinoma.
Portela De Melo, Márcia Bittelbrunn, Ana C Menke, Carlos H De Mendonça Uchoa, Diego Grazziotin Rossato, Luciana Lucena Kortmann, Gustavo Leistner-Segal, Sandra
Molecular medicine reports ,vol(2), issue(5),  

No evidence of correlation between p53 codon 72 polymorphism and risk of bladder or breast carcinoma in Tunisian patients.
Mabrouk, Imed Baccouche, Sami El-Abed, Rym Mokdad-Gargouri, Raja Mosbah, Ali Saïd, Salem Daoud, Jamel Frikha, Mounir Jlidi, Rachid Gargouri, Ali
Annals of the New York Academy of Sciences ,vol(1010), issue(),  Dec.2003

TP53 Gene Pro72Arg (rs1042522) Single Nucleotide Polymorphism as Not a Risk Factor for Colorectal Cancer in the Iranian Azari Population
Asadi, Milad Shanehbandi, Dariush Zarintan, Armin Pedram, Negar Baradaran, Behzad Zafari, Venus Shirmohamadi, Masoud Hashemzadeh, Shahriyar
Asian Pacific journal of cancer prevention : APJCP ,vol(18), issue(12),  Dec.2017

Medline data is available here.

The Search Enterprise

Contact Us